Keto Pepperoni Pizza Chicken Bake

Featured in: Main Dishes

This hearty dish transforms simple chicken breasts into a pizza-inspired masterpiece. Seasoned and seared chicken gets topped with sugar-free marinara, shredded mozzarella, and layers of pepperoni before baking until golden and bubbly. The result captures all the flavors you love about pizza while keeping carbs low and protein high. Perfect for weeknight dinners, meal prep, or feeding a family on a ketogenic diet.

Updated on Tue, 10 Feb 2026 09:19:58 GMT
Keto Pepperoni Pizza Chicken Bake with golden, bubbly mozzarella and pepperoni over baked chicken breasts. Save
Keto Pepperoni Pizza Chicken Bake with golden, bubbly mozzarella and pepperoni over baked chicken breasts. | cheerfulchefs.com

Enjoy all the flavors of your favorite pizza with this Keto Pepperoni Pizza Chicken Bake. This melty, low-carb casserole combines juicy chicken breast with a rich marinara sauce, gooey mozzarella cheese, and classic pepperoni to create the ultimate keto-friendly dining experience. It is a quick and easy American-style dish that fits perfectly into a gluten-free lifestyle.

Keto Pepperoni Pizza Chicken Bake with golden, bubbly mozzarella and pepperoni over baked chicken breasts. Save
Keto Pepperoni Pizza Chicken Bake with golden, bubbly mozzarella and pepperoni over baked chicken breasts. | cheerfulchefs.com

This easy-to-prepare meal yields 4 servings and takes a total of 40 minutes from start to finish. By searing the chicken first, you lock in moisture, ensuring every bite is tender and delicious under a canopy of golden mozzarella.

Ingredients

  • 4 boneless, skinless chicken breasts (about 1.5 lbs / 680 g)
  • 1 tbsp olive oil
  • 1/2 tsp salt
  • 1/4 tsp black pepper
  • 3/4 cup (180 ml) sugar-free marinara sauce
  • 1 1/2 cups (170 g) shredded mozzarella cheese
  • 20 slices pepperoni (about 60 g)
  • 1/2 tsp dried Italian seasoning
  • 1/4 tsp crushed red pepper flakes (optional)
  • 2 tbsp grated Parmesan cheese
  • 2 tbsp chopped fresh basil or parsley (optional garnish)
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Instructions

Step 1
Preheat oven to 400°F (200°C). Lightly grease a 9x13-inch (23x33 cm) baking dish.
Step 2
Pat chicken breasts dry and season both sides with salt and pepper.
Step 3
Heat olive oil in a large skillet over medium-high heat. Sear chicken breasts for 2–3 minutes per side until lightly golden (they do not need to be cooked through).
Step 4
Arrange the seared chicken breasts in the prepared baking dish.
Step 5
Spoon the marinara sauce evenly over the chicken.
Step 6
Sprinkle mozzarella cheese over the sauce-covered chicken.
Step 7
Layer pepperoni slices over the cheese.
Step 8
Sprinkle with Italian seasoning, red pepper flakes (if using), and Parmesan cheese.
Step 9
Bake uncovered for 20–25 minutes, until the chicken is cooked through (internal temp 165°F/74°C) and cheese is bubbly and golden.
Step 10
Let rest for 5 minutes, garnish with fresh basil or parsley if desired, and serve hot.

Zusatztipps für die Zubereitung

Always pat the chicken breasts dry before seasoning to ensure a high-quality sear in the skillet. Using a meat thermometer is recommended to confirm the internal temperature reaches 165°F (74°C), which ensures the chicken is fully cooked while remaining juicy. For the best flavor, check marinara sauce and pepperoni labels for hidden sugars.

Varianten und Anpassungen

For an even juicier variation, you can use chicken thighs instead of breasts. If you prefer a lower-fat option, try turkey pepperoni or omit the pepperoni entirely. You can further customize this casserole by adding sautéed mushrooms, bell peppers, or olives to the topping layer.

Serviervorschläge

This pizza chicken bake is best served hot. For a complete and balanced low-carb meal, pair it with a fresh side salad or a portion of steamed broccoli.

Oven-baked Keto Pepperoni Pizza Chicken Bake served hot with melted cheese and fresh basil garnish. Save
Oven-baked Keto Pepperoni Pizza Chicken Bake served hot with melted cheese and fresh basil garnish. | cheerfulchefs.com

Whether you are following a strict keto diet or just looking for a delicious, high-protein meal, this Keto Pepperoni Pizza Chicken Bake is sure to satisfy. The combination of classic Italian seasonings and gooey mozzarella makes it a repeat-worthy dish for any home cook.

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Recipe FAQs

Can I use chicken thighs instead of breasts?

Yes, boneless chicken thighs work beautifully and often stay juicier during baking. Adjust cooking time to 25-30 minutes, ensuring internal temperature reaches 165°F.

What marinara sauce is best for keto?

Look for sugar-free marinara with 3-5 grams of carbs per serving. Brands like Rao's, Yo Mama's, or make your own by simmering crushed tomatoes with Italian herbs.

Can I make this ahead for meal prep?

Absolutely. Portion leftovers into airtight containers and refrigerate up to 4 days. Reheat at 350°F for 10-15 minutes or microwave until warmed through.

How do I prevent the chicken from drying out?

Searing first locks in juices, and the sauce layer creates moisture. Avoid overcooking—check temperature at 20 minutes and remove when chicken reaches 165°F.

Can I freeze this dish?

Yes, freeze after baking in freezer-safe containers up to 3 months. Thaw overnight in refrigerator and reheat covered at 350°F until hot throughout.

What vegetables can I add?

Sautéed mushrooms, bell peppers, spinach, or olives make excellent additions. Layer them under the cheese so they cook through and stay tender.

Keto Pepperoni Pizza Chicken Bake

Juicy chicken topped with marinara, mozzarella, and pepperoni bakes into a melty, satisfying low-carb dinner ready in under an hour.

Prep Time
10 minutes
Cook Time
30 minutes
Overall Time
40 minutes
Creator Ruby Smiles

Recipe Type Main Dishes

Skill Level Easy

Cuisine Background American

Portions 4 Serves

Dietary Preferences Gluten-Free Option, Low-Carb Option

What You’ll Need

Chicken

01 4 boneless, skinless chicken breasts (about 1.5 lbs)
02 1 tablespoon olive oil
03 1/2 teaspoon salt
04 1/4 teaspoon black pepper

Sauce & Cheese

01 3/4 cup sugar-free marinara sauce
02 1 1/2 cups shredded mozzarella cheese

Toppings

01 20 slices pepperoni
02 1/2 teaspoon dried Italian seasoning
03 1/4 teaspoon crushed red pepper flakes
04 2 tablespoons grated Parmesan cheese

Garnish

01 2 tablespoons chopped fresh basil or parsley

Step-by-Step Guide

Step 01

Prepare baking vessel: Preheat oven to 400°F. Lightly grease a 9x13-inch baking dish.

Step 02

Season chicken: Pat chicken breasts dry and season both sides generously with salt and pepper.

Step 03

Sear chicken: Heat olive oil in a large skillet over medium-high heat. Sear chicken breasts for 2-3 minutes per side until lightly golden. Do not cook through completely.

Step 04

Arrange in baking dish: Transfer seared chicken breasts to the prepared baking dish in a single layer.

Step 05

Add sauce: Spoon marinara sauce evenly over each chicken breast.

Step 06

Layer cheese: Sprinkle mozzarella cheese over the sauce-covered chicken, covering completely.

Step 07

Add pepperoni: Arrange pepperoni slices over the cheese layer.

Step 08

Season topping: Sprinkle Italian seasoning, red pepper flakes, and Parmesan cheese over the pepperoni.

Step 09

Bake casserole: Bake uncovered for 20-25 minutes until chicken reaches an internal temperature of 165°F and cheese is bubbly and golden brown.

Step 10

Rest and finish: Remove from oven and let rest for 5 minutes. Garnish with fresh basil or parsley if desired and serve immediately.

Tools You’ll Need

  • Large skillet
  • 9x13-inch baking dish
  • Tongs
  • Knife and cutting board

Potential Allergens

Inspect ingredients for specific allergens and contact a professional for concerns.
  • Contains dairy: mozzarella and Parmesan cheese
  • Contains pork: pepperoni

Nutritional Details (Per Serving)

Provided as supportive info; always cross-check with your healthcare provider.
  • Calories: 380
  • Fats: 21 grams
  • Carbohydrates: 5 grams
  • Proteins: 42 grams