Keto Spinach Artichoke Chicken Bake

Featured in: Main Dishes

This hearty chicken bake transforms the classic spinach artichoke dip into a satisfying main course. Boneless chicken breasts are seasoned and smothered with a creamy blend of cream cheese, sour cream, and mayonnaise, then loaded with chopped spinach and tender artichoke hearts. The dish gets finished with generous layers of melted mozzarella and Parmesan, creating a golden, bubbly topping that's both indulgent and keto-friendly. Perfect for busy weeknights, this hands-off casserole comes together in just 15 minutes of prep time and bakes to golden perfection in half an hour.

Updated on Mon, 09 Feb 2026 15:01:00 GMT
Golden-brown Keto Spinach Artichoke Chicken Bake fresh from the oven, featuring bubbling mozzarella and Parmesan over creamy spinach and artichoke topping. Save
Golden-brown Keto Spinach Artichoke Chicken Bake fresh from the oven, featuring bubbling mozzarella and Parmesan over creamy spinach and artichoke topping. | cheerfulchefs.com

My kitchen smelled like a spinach artichoke dip exploded the night I first made this casserole, except the magic stayed contained in a baking dish instead of spreading across my countertop. I'd been craving that creamy, indulgent appetizer vibe but wanted something that could actually be dinner, something that wouldn't derail my keto goals. The moment I pulled it out of the oven, golden and bubbling at the edges, I knew I'd found the answer to every weeknight question of what to cook.

I made this for my sister who'd just started keto and was convinced she'd be eating sad chicken and broccoli forever. When she took that first bite and realized the chicken was tender, the topping was luxurious, and there was actual spinach hiding in there doing its job, her whole face changed. She asked for the recipe before she'd even finished her plate, and now it's become her go-to when she wants to prove to skeptics that keto food can be genuinely craveable.

Ingredients

  • Chicken breasts: Use them straight from the fridge without worrying about pounding them thin, since the creamy topping keeps them moist through the bake.
  • Fresh spinach: Chop it roughly and don't worry about excess moisture, the cream cheese mixture absorbs any liquid beautifully.
  • Canned artichoke hearts: Drain them well and chop into bite-sized pieces so they distribute evenly and don't overwhelm any single forkful.
  • Cream cheese: Let it soften on the counter for 10 minutes before mixing, it combines into the sauce without lumps or stubborn pockets.
  • Sour cream and mayonnaise: These create the tangy richness that makes people ask what your secret ingredient is, even though it's just fat and flavor working together.
  • Mozzarella and Parmesan: Split them so half goes into the sauce for creaminess and half tops the casserole for that gorgeous golden crust you see bubbling in the oven window.
  • Garlic, onion powder, and Italian herbs: These humble seasonings prevent the dish from tasting one-note and add depth that makes people forget this came together without fresh herbs or complicated steps.

Instructions

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Start with a hot oven and prepared dish:
Preheat to 400°F and grease your 9x13-inch baking dish so the bottom doesn't stick and pull apart when you plate it. Arrange your chicken breasts in a single layer, leaving a little space between each one so heat circulates and cooks them evenly.
Season the chicken first:
Sprinkle salt, pepper, and Italian herbs directly onto both sides of the breasts. This gives them flavor on their own before the topping touches them, so they taste like intentional chicken, not just a vehicle for sauce.
Build the creamy mixture:
In a bowl, combine softened cream cheese, sour cream, mayonnaise, minced garlic, onion powder, and half of each cheese. Stir until smooth and cohesive, then fold in the chopped spinach and drained artichoke hearts gently so everything distributes.
Top generously and evenly:
Spread the mixture over each chicken breast in an even layer, then scatter the remaining mozzarella and Parmesan across the top. If you like heat, add a pinch of red pepper flakes for a subtle kick that lingers.
Bake until golden and cooked through:
Slide it into the oven uncovered for 25 to 30 minutes, watching for the top to turn golden and bubble slightly at the edges. A meat thermometer reading 165°F in the thickest part confirms the chicken is done without any guesswork.
Rest before serving:
Let it sit for 5 minutes after coming out of the oven so the filling sets slightly and stays on the chicken instead of running onto the plate. This small pause also gives you time to make a quick side salad or pour a drink.
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Dries dishes, utensils, and cookware neatly after cooking, keeping your countertop organized and clutter free.
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Tender chicken breasts smothered in a rich, creamy keto spinach artichoke sauce, baked until the cheese is perfectly melted and golden. Save
Tender chicken breasts smothered in a rich, creamy keto spinach artichoke sauce, baked until the cheese is perfectly melted and golden. | cheerfulchefs.com

My partner actually looked up from his phone at dinner when he tried this, which in our house means something major happened. He asked if I'd gotten it from a restaurant, and when I said no, he had seconds. That's the moment I realized this recipe had transcended the keto category and become just genuinely good food that people actually want to eat.

Why This Replaces Restaurant Cravings

Spinach artichoke dip at restaurants always feels like an indulgence you're supposed to feel guilty about, but when it's served as a chicken casserole on keto, somehow it becomes virtuous. The protein is there, the carbs are low, and nobody's counting calories when something tastes this good. I've stopped suggesting restaurants because I know what I make at home is actually better, and that shift in confidence changes everything about weeknight cooking.

Variations That Work

This casserole is forgiving enough to bend without breaking. I've substituted chicken thighs when breasts seemed boring, and the extra fat made them even more tender and flavorful. One time I added a squeeze of lemon juice before serving, and it brightened everything up like sunlight breaking through clouds. You could fold in fresh basil instead of dried herbs, or add sun-dried tomatoes if you want sweetness without sugar.

Serving and Storage Notes

Serve this straight from the baking dish with a simple green salad or steamed vegetables on the side, which balances the richness without overpowering it. Leftovers actually improve as the flavors meld, and they reheat beautifully in the oven at 350°F for about 10 minutes, or even in a small skillet over medium heat if you want just one portion.

  • Store leftovers in an airtight container in the fridge for up to 3 days, or freeze portions for up to a month if you're meal prepping.
  • If reheating from frozen, thaw in the fridge overnight first, then warm through gently so the chicken doesn't dry out.
  • This casserole also works beautifully as a lunch the next day, cold from the fridge on a bed of greens for a different texture and temperature altogether.
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A close-up of Keto Spinach Artichoke Chicken Bake served on a white plate, highlighting the juicy chicken and chunky artichoke hearts. Save
A close-up of Keto Spinach Artichoke Chicken Bake served on a white plate, highlighting the juicy chicken and chunky artichoke hearts. | cheerfulchefs.com

This recipe proves that keto cooking doesn't mean deprivation, it means strategy and knowing which flavors and fats actually satisfy. Make it once and it becomes part of your regular rotation.

Recipe FAQs

Can I use frozen spinach instead of fresh?

Yes, frozen spinach works well in this dish. Thaw it completely and squeeze out all excess moisture before adding to the cream cheese mixture to prevent a watery result.

What temperature should the chicken reach?

The chicken is safe to eat when it reaches an internal temperature of 165°F (74°C). Use a meat thermometer inserted into the thickest part of the breast to check doneness.

Can I make this ahead of time?

Absolutely. Assemble the entire dish up to 24 hours in advance, cover tightly, and refrigerate. When ready to bake, you may need to add 5-10 extra minutes since it will be cold.

Is this dish freezer-friendly?

You can freeze the unbaked casserole for up to 3 months. Thaw overnight in the refrigerator before baking. Already baked portions can be frozen for 1-2 months and reheated in the microwave or oven.

What vegetables pair well with this?

Steamed broccoli, roasted cauliflower, or a crisp green salad with vinaigrette make excellent low-carb sides. Zucchini noodles or roasted asparagus also complement the rich flavors nicely.

Can I substitute chicken thighs?

Chicken thighs work beautifully and often result in a juicier, more flavorful dish. Adjust cooking time to 30-35 minutes, or until the internal temperature reaches 165°F.

Keto Spinach Artichoke Chicken Bake

Rich, creamy chicken topped with spinach artichoke mixture and melted cheese. A comforting low-carb dinner ready in under an hour.

Prep Time
15 minutes
Cook Time
30 minutes
Overall Time
45 minutes
Creator Ruby Smiles

Recipe Type Main Dishes

Skill Level Easy

Cuisine Background American

Portions 4 Serves

Dietary Preferences Gluten-Free Option, Low-Carb Option

What You’ll Need

Protein

01 4 boneless, skinless chicken breasts, approximately 1.5 pounds

Vegetables

01 2 cups fresh spinach, chopped
02 1 cup canned artichoke hearts, drained and chopped
03 2 cloves garlic, minced

Dairy

01 4 ounces cream cheese, softened
02 ½ cup sour cream
03 ½ cup mayonnaise
04 1 cup shredded mozzarella cheese
05 ½ cup grated Parmesan cheese

Spices and Seasonings

01 ½ teaspoon onion powder
02 ½ teaspoon dried Italian herbs
03 ½ teaspoon salt
04 ¼ teaspoon black pepper
05 Pinch of red pepper flakes, optional

Step-by-Step Guide

Step 01

Prepare baking dish and preheat oven: Preheat oven to 400°F. Lightly grease a 9x13-inch baking dish with cooking spray or butter.

Step 02

Season chicken breasts: Place chicken breasts in the prepared baking dish. Season both sides generously with salt, pepper, and dried Italian herbs.

Step 03

Prepare creamy sauce base: In a medium mixing bowl, combine softened cream cheese, sour cream, mayonnaise, minced garlic, and onion powder. Mix until smooth and well incorporated. Fold in half of the mozzarella and Parmesan cheeses.

Step 04

Incorporate vegetables: Fold chopped spinach and drained artichoke hearts into the cream cheese mixture until evenly distributed.

Step 05

Layer sauce over chicken: Evenly spread the spinach-artichoke mixture over the chicken breasts, covering completely.

Step 06

Top with cheese: Distribute remaining mozzarella and Parmesan cheeses over the top. Sprinkle with red pepper flakes if desired.

Step 07

Bake until cooked through: Bake uncovered for 25 to 30 minutes, or until the internal temperature of the thickest chicken breast reaches 165°F and the top is golden and bubbly.

Step 08

Rest before serving: Remove from oven and allow to rest for 5 minutes before portioning and serving.

Tools You’ll Need

  • 9x13-inch baking dish
  • Medium mixing bowl
  • Sharp knife and cutting board
  • Measuring cups and measuring spoons

Potential Allergens

Inspect ingredients for specific allergens and contact a professional for concerns.
  • Contains dairy products including cheese, cream cheese, and sour cream
  • Contains eggs present in mayonnaise
  • Verify mayonnaise label for egg content and confirm all ingredients for hidden gluten if strict gluten-free diet required

Nutritional Details (Per Serving)

Provided as supportive info; always cross-check with your healthcare provider.
  • Calories: 475
  • Fats: 32 grams
  • Carbohydrates: 6 grams
  • Proteins: 41 grams