One-Pot Cajun Chicken Alfredo

Featured in: Main Dishes

This dish combines tender chicken pieces infused with smoky Cajun spices and cooked alongside orzo pasta. The creamy Alfredo-style sauce, enriched with Parmesan cheese, ties all the flavors together in a comforting, one-pot meal. Aromatic vegetables like garlic, onion, and bell pepper add depth, while optional spinach provides freshness. Perfect for quick, flavorful weeknight cooking, it offers a balance of spice, creaminess, and texture with minimal cleanup.

Updated on Sat, 22 Nov 2025 11:31:00 GMT
One-Pot Cajun Chicken Alfredo Orzo, a creamy, flavorful dish with tender chicken and pasta. Save
One-Pot Cajun Chicken Alfredo Orzo, a creamy, flavorful dish with tender chicken and pasta. | cheerfulchefs.com

A creamy, spicy, and comforting one-pot meal combining tender chicken, smoky Cajun spices, velvety Alfredo sauce, and orzo pasta for a quick weeknight dinner.

This dish brings together rich flavors that satisfy the whole family and always gets rave reviews whenever I make it.

Ingredients

  • Proteins: 2 large boneless skinless chicken breasts (about 450 g) cut into bite sized pieces
  • Vegetables: 1 small yellow onion finely chopped 3 cloves garlic minced 1 red bell pepper diced 1 cup baby spinach roughly chopped (optional)
  • Pantry: 2 tablespoons olive oil 1 1/2 cups (300 g) orzo pasta 2 1/2 cups (600 ml) low sodium chicken broth 1 cup (240 ml) heavy cream 1/2 cup (120 ml) milk
  • Spices & Seasonings: 1 tablespoon Cajun seasoning (store bought or homemade) 1/2 teaspoon smoked paprika 1/2 teaspoon salt or to taste 1/4 teaspoon freshly ground black pepper Pinch of cayenne pepper (optional for extra heat)
  • Cheeses: 3/4 cup (75 g) freshly grated Parmesan cheese
  • Garnish: Chopped fresh parsley Extra Parmesan cheese

Instructions

Season the chicken:
Season the chicken pieces with half of the Cajun seasoning salt and pepper
Cook chicken:
In a large deep skillet or Dutch oven heat olive oil over medium high heat Add the chicken and sauté until browned and just cooked through about 56 minutes Remove chicken to a plate and set aside
Sauté vegetables:
In the same pot add onion and bell pepper Sauté for 3 minutes until softened Add garlic and cook for 1 minute more
Toast orzo and spices:
Stir in the orzo smoked paprika remaining Cajun seasoning and cayenne pepper Toast the orzo for 1 minute stirring frequently
Add liquids:
Pour in the chicken broth heavy cream and milk Stir well scraping any browned bits from the bottom
Simmer:
Bring to a gentle boil then reduce heat to medium low Cover and simmer for 1012 minutes stirring occasionally until orzo is tender and most liquid is absorbed
Combine chicken and spinach:
Return the chicken to the pot along with spinach (if using) Stir in Parmesan cheese until melted and creamy
Adjust seasoning:
Taste and adjust seasoning If sauce is too thick add a splash more milk or broth
Serve:
Serve hot garnished with parsley and extra Parmesan
Imagine a vibrant photo of One-Pot Cajun Chicken Alfredo Orzo, topped with fresh parsley and Parmesan. Save
Imagine a vibrant photo of One-Pot Cajun Chicken Alfredo Orzo, topped with fresh parsley and Parmesan. | cheerfulchefs.com

This recipe always brings my family together around the dinner table and creates lasting memories.

Notes

Add mushrooms or peas for extra vegetables Serve with crusty bread or a green salad

Required Tools

Large deep skillet or Dutch oven with lid Cutting board and knife Wooden spoon or spatula Measuring cups and spoons Grater (for Parmesan)

Allergen Information

Contains Dairy (cream milk Parmesan) Wheat (orzo) Possible Celery (in broth) Check Cajun seasoning and broth labels for hidden allergens

This comforting bowl of One-Pot Cajun Chicken Alfredo Orzo features succulent chicken and a rich Alfredo sauce. Save
This comforting bowl of One-Pot Cajun Chicken Alfredo Orzo features succulent chicken and a rich Alfredo sauce. | cheerfulchefs.com

This creamy Cajun chicken Alfredo orzo is sure to be a family favorite in just one pot.

Recipe FAQs

Can I substitute the chicken with another protein?

Yes, shrimp or smoked sausage make excellent substitutes, offering different textures and flavors while keeping the dish hearty.

What is the best way to adjust the spiciness level?

To reduce heat, use less or omit the cayenne pepper. For more spice, increase the Cajun seasoning or add extra cayenne carefully.

How can I make this dish creamier?

Adding a bit more heavy cream or stirring in extra Parmesan cheese while cooking will increase creaminess and richness.

Is orzo pasta essential or can it be replaced?

Orzo provides a unique texture but can be replaced with small pasta shapes like couscous or rice for similar results.

Can I prepare this dish in advance?

It’s best served fresh, but leftover portions can be refrigerated and gently reheated, adding a splash of milk or broth to loosen the sauce.

What vegetables work well besides spinach?

Mushrooms, peas, or kale are great alternatives or additions, adding flavor and nutrition.

One-Pot Cajun Chicken Alfredo

Creamy, spicy chicken and orzo with smoky Cajun flavors and rich Alfredo sauce in one pot.

Prep Time
15 minutes
Cook Time
25 minutes
Overall Time
40 minutes
Creator Ruby Smiles

Recipe Type Main Dishes

Skill Level Easy

Cuisine Background American, Cajun-Inspired

Portions 4 Serves

Dietary Preferences None specified

What You’ll Need

Proteins

01 2 large boneless, skinless chicken breasts, cut into bite-sized pieces

Vegetables

01 1 small yellow onion, finely chopped
02 3 cloves garlic, minced
03 1 red bell pepper, diced
04 1 cup baby spinach, roughly chopped (optional)

Pantry

01 2 tablespoons olive oil
02 1 1/2 cups orzo pasta
03 1 cup low-sodium chicken broth
04 1 cup heavy cream
05 1/2 cup milk

Spices & Seasonings

01 1 tablespoon Cajun seasoning
02 1/2 teaspoon smoked paprika
03 1/2 teaspoon salt, or to taste
04 1/4 teaspoon freshly ground black pepper
05 Pinch of cayenne pepper (optional)

Cheeses

01 3/4 cup freshly grated Parmesan cheese

Garnish

01 Chopped fresh parsley
02 Extra Parmesan cheese

Step-by-Step Guide

Step 01

Season chicken: Combine chicken pieces with half of the Cajun seasoning, salt, and black pepper.

Step 02

Brown chicken: Heat olive oil in a large deep skillet over medium-high heat. Sauté chicken until browned and just cooked through, about 5 to 6 minutes. Remove and set aside.

Step 03

Sauté vegetables: Add chopped onion and red bell pepper to the same skillet. Cook for 3 minutes until softened, then add garlic and cook another minute.

Step 04

Toast orzo and spices: Stir in orzo pasta, smoked paprika, remaining Cajun seasoning, and cayenne pepper. Toast for 1 minute, stirring frequently.

Step 05

Add liquids: Pour in chicken broth, heavy cream, and milk. Stir well, scraping up any browned bits from the bottom.

Step 06

Simmer mixture: Bring to a gentle boil, reduce heat to medium-low, cover, and simmer for 10 to 12 minutes, stirring occasionally, until orzo is tender and most liquid is absorbed.

Step 07

Combine chicken and spinach: Return chicken to the skillet with spinach, if using. Stir in Parmesan cheese until the sauce is melted and creamy.

Step 08

Adjust seasoning: Taste and adjust salt and pepper as needed. Add a splash of milk or broth if sauce is too thick.

Step 09

Serve garnished: Plate the dish hot, garnished with chopped parsley and extra Parmesan cheese.

Tools You’ll Need

  • Large, deep skillet or Dutch oven with lid
  • Cutting board and knife
  • Wooden spoon or spatula
  • Measuring cups and spoons
  • Grater for Parmesan cheese

Potential Allergens

Inspect ingredients for specific allergens and contact a professional for concerns.
  • Contains dairy and wheat; may contain celery. Verify Cajun seasoning and broth for hidden allergens.

Nutritional Details (Per Serving)

Provided as supportive info; always cross-check with your healthcare provider.
  • Calories: 570
  • Fats: 27 grams
  • Carbohydrates: 48 grams
  • Proteins: 37 grams