One-Pot Cajun Chicken Alfredo

Featured in: Main Dishes

This one-pot dish combines tender chicken breast with al dente orzo pasta in a creamy Cajun Alfredo sauce. Cooked in a single skillet, the meal features sautéed onions, garlic, and a spice blend of Cajun seasoning, smoked paprika, and red pepper flakes. The sauce is enriched with heavy cream and fresh Parmesan, creating a smooth, flavorful coating. Garnished with fresh parsley, this hearty dish comes together in just 30 minutes, perfect for quick and satisfying weeknight meals.

Updated on Sat, 22 Nov 2025 15:16:00 GMT
One-Pot Cajun Chicken Alfredo Orzo, a creamy, savory pasta dish with flavorful chicken and sauce. Save
One-Pot Cajun Chicken Alfredo Orzo, a creamy, savory pasta dish with flavorful chicken and sauce. | cheerfulchefs.com

A quick and creamy one-pot meal that blends tender chicken, al dente orzo, and a zesty Cajun Alfredo sauce. Perfect for busy weeknights, this dish delivers bold flavors and comforting richness in just 30 minutes.

This creamy Cajun chicken Alfredo orzo quickly became a go-to recipe on busy nights. I love how everything cooks in one pot and the rich sauce is always a hit with my family.

Ingredients

  • Chicken: 1 lb (450 g) chicken breast, diced (substitute with shrimp or Andouille sausage if desired); Salt and black pepper, to taste
  • Spice Blend: 1 tbsp Cajun seasoning (adjust for spice preference); 1 tsp smoked paprika (regular paprika can be used); 1/4 tsp red pepper flakes (optional, for extra heat)
  • Base: 2 tbsp olive oil; 2 tbsp butter; 1 medium onion, chopped (yellow or sweet preferred); 3 cloves garlic, minced
  • Pasta: 1 cup (190 g) orzo pasta (substitute with other small pasta if needed)
  • Sauce: 2 cups (480 ml) low-sodium chicken broth; 1 cup (240 ml) heavy cream (or half and half for a lighter version); 1 cup (90 g) Parmesan cheese, freshly grated
  • Garnish: 1 tbsp fresh parsley, chopped

Instructions

Step 1:
Heat olive oil and butter in a large skillet over medium high heat. Add diced chicken, season with salt and pepper, and sear for 34 minutes until golden brown. Remove chicken and set aside.
Step 2:
In the same skillet, add chopped onion and sauté for 23 minutes until translucent. Stir in minced garlic and cook for 1 minute until fragrant.
Step 3:
Add orzo pasta to the skillet, stirring to combine. Toast for 12 minutes until lightly golden.
Step 4:
Pour in chicken broth and sprinkle in Cajun seasoning, smoked paprika, and red pepper flakes. Stir well, bring to a boil, then reduce heat to low. Cover and simmer for 1012 minutes, stirring occasionally, until orzo is al dente and most of the liquid is absorbed.
Step 5:
Remove skillet from heat. Gradually stir in heavy cream and Parmesan cheese until the sauce is creamy and smooth.
Step 6:
Return the cooked chicken to the skillet and stir to combine. Heat through for 1 minute. Taste and adjust seasoning as needed.
Step 7:
Garnish with fresh parsley before serving.
Save
| cheerfulchefs.com

My family always gathers around this dish and loves how the creamy sauce complements the tender chicken and perfectly cooked orzo.

Serving Suggestions

Serve with crusty bread or a fresh green salad to round out the meal.

Variations

Add bell peppers or spinach for extra vegetables and color.

Wine Pairing

This dish pairs well with a chilled Sauvignon Blanc or a light lager.

Savory One-Pot Cajun Chicken Alfredo Orzo with a rich sauce and tender chicken, ready in minutes. Save
Savory One-Pot Cajun Chicken Alfredo Orzo with a rich sauce and tender chicken, ready in minutes. | cheerfulchefs.com

This dish combines ease and bold flavor—a perfect weeknight meal that feels special.

Recipe FAQs

Can I substitute the chicken with other proteins?

Yes, shrimp or Andouille sausage work well as alternatives; adjust cooking times accordingly to ensure proper doneness.

How do I make the dish less creamy?

Use half and half instead of heavy cream, and reduce the amount of Parmesan cheese for a lighter sauce.

What pasta can replace orzo in this dish?

Small pasta shapes like acini di pepe or fregola can substitute orzo for similar texture and cooking times.

Can I add vegetables to this dish?

Yes, bell peppers, spinach, or other quick-cooking vegetables add color and nutrition when stirred in during cooking.

What wine pairs well with this meal?

A chilled Sauvignon Blanc or a light lager complements the bold Cajun flavors and creamy sauce nicely.

One-Pot Cajun Chicken Alfredo

A creamy one-pot dish blending Cajun-seasoned chicken and tender orzo in a rich sauce.

Prep Time
10 minutes
Cook Time
20 minutes
Overall Time
30 minutes
Creator Ruby Smiles

Recipe Type Main Dishes

Skill Level Easy

Cuisine Background Cajun

Portions 4 Serves

Dietary Preferences None specified

What You’ll Need

Chicken

01 1 lb diced chicken breast
02 Salt, to taste
03 Black pepper, to taste

Spice Blend

01 1 tbsp Cajun seasoning
02 1 tsp smoked paprika
03 1/4 tsp red pepper flakes (optional)

Base

01 2 tbsp olive oil
02 2 tbsp butter
03 1 medium onion, chopped
04 3 cloves garlic, minced

Pasta

01 1 cup orzo pasta

Sauce

01 2 cups low-sodium chicken broth
02 1 cup heavy cream
03 1 cup freshly grated Parmesan cheese

Garnish

01 1 tbsp fresh parsley, chopped

Step-by-Step Guide

Step 01

Sear Chicken: Heat olive oil and butter in a large skillet over medium-high heat. Season diced chicken with salt and pepper, then sear for 3 to 4 minutes until golden. Remove and set aside.

Step 02

Sauté Aromatics: In the same skillet, cook chopped onion for 2 to 3 minutes until translucent. Add minced garlic and cook for 1 minute until fragrant.

Step 03

Toast Orzo: Stir in orzo pasta and toast for 1 to 2 minutes until lightly golden.

Step 04

Simmer Pasta: Pour in chicken broth and add Cajun seasoning, smoked paprika, and red pepper flakes. Stir and bring to a boil. Reduce heat to low, cover, and simmer for 10 to 12 minutes, stirring occasionally until orzo is al dente and liquid is mostly absorbed.

Step 05

Incorporate Cream and Cheese: Remove skillet from heat. Gradually stir in heavy cream and Parmesan cheese until creamy and smooth.

Step 06

Combine Chicken: Return cooked chicken to skillet and stir to combine. Heat through for 1 minute and adjust seasoning as needed.

Step 07

Garnish and Serve: Sprinkle fresh parsley on top before serving.

Tools You’ll Need

  • Large skillet with lid
  • Wooden spoon or spatula
  • Chef’s knife
  • Cutting board
  • Measuring cups and spoons
  • Grater for Parmesan cheese

Potential Allergens

Inspect ingredients for specific allergens and contact a professional for concerns.
  • Contains dairy (butter, cream, Parmesan cheese) and gluten (orzo pasta).

Nutritional Details (Per Serving)

Provided as supportive info; always cross-check with your healthcare provider.
  • Calories: 560
  • Fats: 28 grams
  • Carbohydrates: 45 grams
  • Proteins: 35 grams