Creamy Cajun Chicken Pasta

Featured in: Main Dishes

This dish features juicy strips of chicken sautéed with Cajun spices, combined with sautéed bell peppers and red onion. Tossed in a creamy, reduced-fat sauce enriched with cream cheese, milk, and Parmesan, it delivers a smooth texture and tangy lemon zest. Whole wheat penne pasta absorbs the flavors, creating a balanced and lighter meal with vibrant colors and satisfying warmth. Perfect for a quick, flavorful dinner ready in just 40 minutes.

Updated on Mon, 12 Jan 2026 13:03:00 GMT
Creamy Cajun Chicken Pasta Lite with colorful peppers and tender chicken ready to enjoy. Save
Creamy Cajun Chicken Pasta Lite with colorful peppers and tender chicken ready to enjoy. | cheerfulchefs.com

The first time I made this lighter version of Cajun chicken pasta, my husband actually asked if I was sure it was the "healthy" version. The sauce was so velvety and the spices so bold that nobody at the table believed we were eating something with half the usual calories. Now it is my go-to when I want comfort food that does not leave me feeling weighed down afterward.

Last winter my sister came over for dinner completely exhausted from work, and I put this steaming bowl in front of her. She took one bite, closed her eyes, and actually said she felt like she was at a restaurant. That moment of watching someone find comfort in something I cooked is exactly why this recipe stays in regular rotation.

Ingredients

  • Whole wheat penne: The nutty flavor stands up beautifully to the bold Cajun spices
  • Chicken breasts: Slice them into even strips so they cook uniformly and stay juicy
  • Cajun seasoning blend: This is the flavor backbone, so do not be shy with it
  • Bell peppers: Red and yellow add sweetness to balance the heat
  • Reduced-fat cream cheese: Creates that luxurious sauce texture without the heaviness
  • Lemon: The zest brightens everything while juice cuts through the richness

Instructions

Get the pasta going:
Cook the penne until al dente, then drain but save that pasta water—it is liquid gold for adjusting sauce consistency later.
Season the chicken well:
Toss those strips thoroughly with all the spices so every bite packs flavor, not just the lucky ones.
Sear until golden:
Let the chicken develop a nice crust in the hot olive oil, about 4 to 5 minutes per side, then set it aside.
Soften the vegetables:
Cook the peppers and onions until they are tender and fragrant, then add the garlic for just a minute so it does not burn.
Build the creamy sauce:
Return the chicken to the pan, stir in the cream cheese and milk until smooth, and add pasta water only if needed.
Bring it all together:
Toss in the cooked penne, Parmesan, lemon zest and juice, then season to taste before serving.
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This dish has become my default for new parents, sick friends, or anyone who needs a hug in a bowl. Something about the combination of warming spices and creamy comfort just feels like being taken care of.

Making It Your Own

Swap chicken for shrimp or even cubes of firm tofu if you want a plant-based version. Sometimes I throw in spinach at the end for extra nutrients, and it wilts perfectly into the sauce.

Heat Level Hacks

If your family is spice-sensitive, start with half the Cajun seasoning and let everyone add more at the table. A pinch of cayenne can totally transform the final kick.

Serving Suggestions

A crisp green salad with a tart vinaigrette cuts through the richness beautifully. I also love a piece of crusty whole grain bread to soak up every drop of sauce.

  • Let the sauce rest for 2 minutes before serving so it thickens slightly
  • Extra Parmesan on top is never a bad decision
  • Leftovers reheat surprisingly well with a splash of milk
A delicious bowl of Creamy Cajun Chicken Pasta Lite, perfectly plated with a parsley garnish. Save
A delicious bowl of Creamy Cajun Chicken Pasta Lite, perfectly plated with a parsley garnish. | cheerfulchefs.com

Hope this brings as much comfort to your table as it has to mine.

Recipe FAQs

What pasta works best with this dish?

Whole wheat penne is recommended for its texture and ability to hold the creamy sauce well, but other pasta shapes like rigatoni or fusilli can also work.

Can the chicken be substituted?

Yes, shrimp or tofu can be used as alternatives to provide different textures while maintaining the flavor profile.

How can I adjust the spice level?

Adding a pinch of cayenne pepper or extra Cajun seasoning will increase the heat, while omitting them will create a milder flavor.

How is the creamy sauce prepared?

The sauce is made by melting reduced-fat cream cheese into low-fat milk, then enriched with Parmesan cheese, lemon zest, and juice for a tangy, smooth consistency.

Can this dish be made ahead?

It’s best served fresh, but leftovers can be stored in the fridge for up to 2 days and reheated gently to preserve texture and flavor.

Creamy Cajun Chicken Pasta

Tender chicken and al dente penne cooked in a rich, spicy Cajun sauce with colorful peppers and a hint of lemon.

Prep Time
15 minutes
Cook Time
25 minutes
Overall Time
40 minutes
Creator Ruby Smiles

Recipe Type Main Dishes

Skill Level Easy

Cuisine Background American (Cajun-inspired)

Portions 4 Serves

Dietary Preferences None specified

What You’ll Need

Pasta

01 10 oz whole wheat penne

Chicken

01 2 large boneless, skinless chicken breasts (14 oz), sliced into strips
02 1 tbsp olive oil
03 1 tsp Cajun seasoning
04 1/2 tsp smoked paprika
05 1/2 tsp garlic powder
06 1/2 tsp salt
07 1/4 tsp black pepper

Vegetables

01 1 red bell pepper, thinly sliced
02 1 yellow bell pepper, thinly sliced
03 1 small red onion, thinly sliced
04 2 cloves garlic, minced

Sauce

01 2/3 cup reduced-fat cream cheese
02 1/2 cup low-fat milk
03 1/4 cup grated Parmesan cheese
04 Zest and juice of 1/2 lemon
05 1 tbsp fresh parsley, chopped

Step-by-Step Guide

Step 01

Cook pasta: Boil penne according to package directions until al dente. Drain, reserving 1/4 cup pasta water, and set aside.

Step 02

Season chicken: In a medium bowl, combine chicken strips with Cajun seasoning, smoked paprika, garlic powder, salt, and black pepper.

Step 03

Sauté chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken strips for 4 to 5 minutes until golden and cooked through. Remove from skillet and set aside.

Step 04

Cook vegetables: In the same skillet, add bell peppers and red onion. Sauté for 4 to 5 minutes until softened. Add minced garlic and cook for an additional minute.

Step 05

Prepare sauce and combine: Reduce heat to medium. Return chicken to the skillet and stir in cream cheese and milk until smooth. Add reserved pasta water if sauce is too thick.

Step 06

Add cheese and pasta: Mix in Parmesan cheese, lemon zest, and juice. Toss in cooked penne until evenly coated.

Step 07

Finish and garnish: Adjust seasoning to taste and garnish with chopped fresh parsley before serving.

Tools You’ll Need

  • Large pot
  • Large skillet
  • Wooden spoon or spatula
  • Knife and cutting board
  • Measuring cups and spoons

Potential Allergens

Inspect ingredients for specific allergens and contact a professional for concerns.
  • Contains milk (cream cheese, Parmesan, milk) and wheat (pasta). Verify Cajun seasoning for possible allergens and gluten.

Nutritional Details (Per Serving)

Provided as supportive info; always cross-check with your healthcare provider.
  • Calories: 420
  • Fats: 10 grams
  • Carbohydrates: 52 grams
  • Proteins: 32 grams